As with the first Guitar Hero On Tour, which arrived on June 22 2008, and the November-released sequel Decades, Modern Hits will make use of the Guitar Grip add-on that plugs into the DS's GBA slot--something the new DSi model lacks.

1. 12 Stones - "Adrenalin"
2. AFI - "Miss Murder"
3. Angels & Airwaves - "Call to Arms"
4. Atreyu - "Falling Down"
5. Black Tide - "Shockwave"
6. Coldplay - "Violet Hill"
7. Endeverafter - "I Wanna Be Your Man"
8. Evanescence - "Sweet Sacrifice"
9. Fall Out Boy - "This Ain't A Scene, It's An Arms Race"
10. Finger Eleven - "Paralyzer"
11. Foo Fighters - "All My Life"
12. Franz Ferdinand - "The Fallen"
13. Kaiser Chiefs - "Ruby"
14. Lenny Kravitz - "Where Are We Runnin'?"
15. Modest Mouse - "Dashboard"
16. Phantom Planet - "Do The Panic"
17. Sum 41 - "Still Waiting"
18. Tenacious D - "The Metal"
19. The Bravery - "Unconditional"
20. The Donnas - "What Do I Have to Do"
21. The Duke Spirit - "Lassoo"
22. The Fratellis - "Chelsea Dagger"
23. The Kooks - "Always Where I Need to Be"
24. The Offspring - "Half-Truism"
25. The Strokes - "Reptilia"
26. Weezer - "Everybody Get Dangerous"
27. Wolfmother - "Dimension"
28. Yellowcard - "Lights and Sounds"