A cover system will be incorporated into the control mechanics for the first time in the franchise's history, allowing players to "lock to a wall and fire around the corner." A dodging mechanic in the style of Clover's God Hand, which used the right analog stick for quick movement, will also be featured.

Expected at some unspecified point in 2009, Resident Evil 5 (PS3, 360) pairs series lead Chris Redfield with an unnamed female mercenary as they investigate the root of all zombie-kind.

When another player is not present, the other character will be AI-controlled. The game will separate the duo at points, a la Gears of War, and sport more open areas than previous RE titles.

The preview further confirmed that the Mercenaries mini-game, a challenge mode first featured in Resident Evil 3 and refined in the fourth title, will return in RE5.