Little League World Series 2008 offers players the ability to bat, pitch and field using controls developed exclusively for the Wii and DS, and is the first officially licensed Little League to hit "next-gen" consoles.

The game is said to feature sixteen teams—eight from the United States and eight international—character customization, World Series mode and a variety of skill-based challenges. Activision did not disclose the name of the studio developing Little League.